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STochastic Engine for Pathway Simulation built by guoguo completed Thu, 29 Oct 2026 23:36:12 UTC

Description

STEPS is a package for exact stochastic simulation of reaction-diffusion systems in arbitrarily complex 3D geometries. Our core simulation algorithm is an implementation of Gillespie's SSA, extended to deal with diffusion of molecules over the elements of a 3D tetrahedral mesh. While it was mainly developed for simulating detailed models of neuronal signaling pathways in dendrites and around synapses, it is a general tool and can be used for studying any biochemical pathway in which spatial gradients and morphology are thought to play a role. STEPS also supports accurate and efficient computational of local membrane potentials on tetrahedral meshes, with the addition of voltage-gated channels and currents. Tight integration between the reaction-diffusion calculations and the tetrahedral mesh potentials allows detailed coupling between molecular activity and local electrical excitability. We have implemented STEPS as a set of Python modules, which means STEPS users can use Python scripts to control all aspects of setting up the model, generating a mesh, controlling the simulation and generating and analyzing output. The core computational routines are still implemented as C/C++ extension modules for maximal speed of execution. STEPS 3.0.0 and above provide early parallel solution for stochastic spatial reaction-diffusion and electric field simulation. Documentation can be found here: http://steps.sourceforge.net/manual/manual_index.html

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Changelog

* Wed Jul 22 2026 Python Maint <python-maint@redhat.com> - 3.6.0-53
- Rebuilt for Python 3.15.0b4 ABI change

* Thu Jul 16 2026 Fedora Release Engineering <releng@fedoraproject.org> - 3.6.0-52
- Rebuilt for https://fedoraproject.org/wiki/Fedora_45_Mass_Rebuild

* Thu Jun 04 2026 Python Maint <python-maint@redhat.com> - 3.6.0-51
- Rebuilt for Python 3.15

* Thu Apr 23 2026 Benjamin A. Beasley <code@musicinmybrain.net> - 3.6.0-50
- Fix accidental use of non-baseline ISA extensions (-march=native)

* Sat Jan 17 2026 Fedora Release Engineering <releng@fedoraproject.org> - 3.6.0-49
- Rebuilt for https://fedoraproject.org/wiki/Fedora_44_Mass_Rebuild

* Wed Nov 12 2025 Benjamin A. Beasley <code@musicinmybrain.net> - 3.6.0-48
- Rebuilt for gtest 1.17.0

* Mon Nov 03 2025 Benjamin A. Beasley <code@musicinmybrain.net> - 3.6.0-47
- Build as C++17 for compatibility with gtest 1.17

* Sat Oct 18 2025 Antonio Trande <sagitter@fedoraproject.org> - 3.6.0-46
- Rebuild for petsc-3.24.0

* Fri Sep 19 2025 Python Maint <python-maint@redhat.com> - 3.6.0-45
- Rebuilt for Python 3.14.0rc3 bytecode

* Fri Aug 15 2025 Python Maint <python-maint@redhat.com> - 3.6.0-44
- Rebuilt for Python 3.14.0rc2 bytecode

* Tue Aug 05 2025 Charalampos Stratakis <cstratak@redhat.com> - 3.6.0-43
- Fix compatibility with Cython >= 3.1
- Fixes: rhbz#2377054

* Fri Jul 25 2025 Fedora Release Engineering <releng@fedoraproject.org> - 3.6.0-42
- Rebuilt for https://fedoraproject.org/wiki/Fedora_43_Mass_Rebuild

* Tue Jun 03 2025 Python Maint <python-maint@redhat.com> - 3.6.0-41
- Rebuilt for Python 3.14

* Mon Apr 28 2025 Antonio Trande <sagitter@fedoraproject.org> - 3.6.0-40
- Rebuild for petsc-3.23.0

* Wed Jan 22 2025 Benjamin A. Beasley <code@musicinmybrain.net> - 3.6.0-39
- Rebuilt for gtest 1.15.2

* Sat Jan 18 2025 Fedora Release Engineering <releng@fedoraproject.org> - 3.6.0-38
- Rebuilt for https://fedoraproject.org/wiki/Fedora_42_Mass_Rebuild

* Mon Jul 29 2024 Miroslav Suchý <msuchy@redhat.com> - 3.6.0-37
- convert GPLv2 license to SPDX